ABSTRACT
OBJECTIVE: To share the process of analysis and intervene the adverse drug reaction (ADR) caused by octreotide, and to provide reference for the work mode of clinical pharmacist. METHODS: One case of hypoglycemia possibly caused by octreotide was discovered. The clinical pharmacist recommend the doctor to replace octreotide as somatostatin after a review of the relevant information and literatures. Then the clinical pharmacist investigated awareness of hypoglycemia ADR of octreotide among the ICU doctors, and introduced the ADR of octreotide and the difference between octreotide and somatostatin among them. RESULTS: After the intervention, the hypoglycemia was corrected and the patient was cured and clinical pharmacists' working mode was identified. CONCLUSION: Clinically, pharmacists should not only have good professional knowledge, but also master the ways and means of communication, in addition to assisting doctors monitoring of adverse drug reactions, also need to continue to explore the work mode.
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the relationship between high-performance liquid chromatography (HPLC) fingerprints of the chloroform extract fractions of Peucedanum harrysmithii var. subglabrum (PHS) and its phlegm-reducing effect, in order to establish "active component group for reducing phlegm".</p><p><b>METHOD</b>HPLC was adopted to determine and analyze HPLC fingerprints of chloroform extract fractions of PHS. Phenol red expectorant experiment was used to observe the phlegm-reducing effect in mice. Mice were administered intragastrically with chloroform extract fractions for 6 days (1.4 g x kg(-1)), with acute bronchitis syrup as the positive control drug (12 mL x kg(-1)). The phenol red secretion in mice was determined by spectrophotometer. Then the grey relational analysis was used to study the spectrum-effect relationship.</p><p><b>RESULT</b>The phlegm-reducing effect of the chloroform extract fractions of PHS were resulted from the combined effect of all of its chemical components. Its various characteristic peaks represented different chemical components, and the order of their contributions to the phlegm-reducing effect was (number of peaks) 13 > 12 > 16 > 18 > 19 > 6 > 20 > 14 > 1 > 11 > 15 > 10 > 17 > 2 > 5 > 4 > 7 > 3 > 8 > 9, in No. 1, 3, 4, 10, 13 and 16 characteristic peaks were identified as marmesin, psoralen, xanthotoxin, Pd-Ib, pteryxin and peuformosin.</p><p><b>CONCLUSION</b>The chloroform extract fractions of PHS show strongly phlegm-reducing effect. There may be certain relationship between their HPLC fingerprint and phlegm-reducing effect.</p>